Treatment Options So Far

Wanted to do a post about the treatment options that we have found so far that may be beneficial and help explain why we would need donations in order to do them. I also want to do this in hope that it maybe will help someone else who is looking for treatment options for Glioblastoma, since the standard care offered is not a cure.

The Standard Treatment

The Standard Treatment for glioblastoma is chemo plus radiation. They also told us this is not a cure and would only extend life maybe by a few months since he's not methylated. Normally for glioblastoma they do a brain map and radiate only where the tumor is to help preserve the good tissue. Now that they say it is leptomeningeal they would need to radiate his entire brain and spine, which has irreversible effects. Both chemo and full brain/spine radiation will give bad side effects making him miserable and causing possible irreversible cognitive problems.

At this point we have pretty much decided against the standard treatment since all it would do is more harm than good for our dad and we need to do another option and fast.

CAR-T Immunotherapy

CAR-T Immunotherapy is the most promising option we have researched, but it is only being done through clinical trials (that we know of). CAR T cell therapy engineers the T cells with CARs to promote immune targeting of cancer cells. Since my dad doesn't fit inside of the trial criteria, since he now has the rare Lepto complication, the doctors say it is unlikely any of the trials will take him. If anyone knows how to receive this therapy outside of a clinical trial or any trials that include lepto patients we would be eternally grateful. We do have an appointment at City of Hope next week in California who may have a CAR-T trials that involves lepto, but we won't know until we get there and they do some further testing on my dad. We have been waiting for an appointment with them for weeks now.

CancerNeo Vaccine

"CeGaT’s CancerNeo enables the analysis of a patient’s tumor exome to detect tumor-specific (somatic) mutations, identifies the HLA-types, and predicts neoantigens. The expression of these neoantigens is confirmed by whole RNA sequencing (transcriptome) from the same tumor sample. Thus, CancerNeo® provides the insights required for the design of personalized cancer vaccines – a powerful tool to boost the immune system’s response to cancer cells."

This is seems very promising, but it is 80k to do it. We send the actual cancer tissue of my dad's tumor to them in Germany and they would create a vaccine specific for him and then a doctor here would administer it. We cannot afford this option without major donations.

Off Label Drugs

Mebendazole, an anti-parasitic drug, has been explored for its potential use in treating brain cancer, particularly glioblastoma, due to its ability to penetrate the blood-brain barrier and inhibit the malignant progression of glioma cells.

Abemaciclib, a selective CDK4/6 inhibitor, has shown potential in treating various types of brain cancers, including high-grade gliomas and diffuse midline gliomas.

Ogremorphin (OGM) is a drug-like compound that has shown promising results in laboratory experiments for treating glioblastoma, the most common and currently incurable form of brain cancer.

Salicinium IV

This is another promising immunotherapy option we found for my dad, but it isn't covered by insurance and isn't in a trial, so it costs thousands and thousands of dollars to get for my dad. Here is a link that talks about it. This is one of the reasons we wanted to ask for some donations so we could possibly afford this promising, and more natural, treatment.

What we are currently doing to stop the growth of the cancer.

Orasal Liquid

This a way to get some of the benefits from the Salicinium IV, but more affordable, in the meantime. Orasal contains the Salicinium molecule. The Salicinium molecule interrupts the fermentation process thus enabling your own immune system to destroy those diseased cells. Orasal and the Salicinium molecule it contains are immune system modulators.

It is a cheaper option, but will still cost us hundreds of dollars a month, but not thousands like the IV. It has the same effects, but works much slower than the IV and time is limited for our dad. We bought this and started him on it on Friday.

Probiotics

I have been doing extensive research since a discovery I had yesterday about the link between bacteria and glioblastoma. I was researching what good bacteria to introduce that will help fight off the bad bacteria that are running the show in my dad's cancer. I have found some pretty promising studies about the affect of Lactobacillus Acidophilus and Kefir on gliomas (and also lots of other types of cancer).

React Supplement

React causes an immune reaction by stimulating your immune system. React will replace you own immune globulins. The enzymes and good bacteria are beneficial for you digestion and immune function.

Alkaline Environment

Another method we have started is trying to get my dad's body to be a more alkaline environment, which cancer cells cannot thrive in. This involves buying some phenomenal water and mixing with distilled water. This, plus a supplement called alk-align we had him start taking.

As you can see, most of the treatment options we are left with will cost a lot of money and my dad can't work now, since this happened. Me and most of my siblings have been not working since diagnosis so that we can help with my dad. He needs constant care and we also want to spend as much time with him as we can before this thing progresses and his brain begins functioning even less, than it already is beginning to now. I have been traveling the 5 hours round trip multiple times a week to see him, and help my family, which takes time and resources to accomplish.

Every donation, even small, is very helpful to us and gives us more hope that we will have the funds necessary to try to stop the growth of this aggressive, fast growing cancer ASAP.

Donations go to his wife, Frances Young:

Zelle/Apple Pay :: 520-808-0081

Venmo :: Fran-Young-12

Paypal :: fatfreestuff@yahoo.com